Serum leptin, adiponectin and ghrelin concentrations in post-menopausal women: Is there an association with bone mineral density?. (June 2016)

• Record Type: Journal Article
• Authors: Mpalaris, V.; Anagnostis, P.; Anastasilakis, A.D.; Goulis, D.G.; Doumas, A.; Iakovou, I.
• Is Part Of: Maturitas. Volume 88(2016)
• Page Start: 32
• Page End: 36
• Publication Date: 2016-06
• Subjects: BMD bone mineral density -- BMI body mass index -- CV co-efficient of variation -- DXA Dual-energy X-ray Absorptiometry -- ELISA enzyme-linked immunosorbent assay -- IRMA immunoradiometric -- IQR interquartile range -- RANK receptor activator of nuclear factor k -- RIA radioimmunoassay -- SHBG sex hormone-binding globulin -- WHR waist-to-hip ratio; Adipokine -- Adiponectin -- Ghrelin -- Leptin -- Osteoporosis; Climacteric -- Periodicals; Menopause -- Periodicals; Climacteric -- Periodicals; Geriatrics -- Periodicals; Menopause -- Periodicals; Middle Aged -- Periodicals; Climatère -- Périodiques; Ménopause -- Périodiques; Climacterium; Climacteric; Menopause; Electronic journals; Periodicals; 612.66
• DOI: 10.1016/j.maturitas.2016.03.004
• Languages: English
• ISSNs: 0378-5122

Abstract

Highlights: Adiponectin is inversely associated with femoral neck BMD in post-menopausal women, independently of body weight. Osteoporotic women have lower BMI and leptin concentrations, but higher adiponectin concentrations compared with non-osteoporotic women. Leptin is positively associated with BMD but this association is dependent on body weight. Abstract: Objective: Adipokines and ghrelin exert well-documented effects on energy expenditure and glucose metabolism. Experimental data also support a role in bone metabolism, although data from clinical studies are conflicting. The purpose of this cross-sectional study was to investigate the association of serum concentrations of leptin, adiponectin and ghrelin with bone mineral density (BMD) in post-menopausal women. Methods: BMD in lumbar spine and femoral neck, and circulating leptin, adiponectin and ghrelin concentrations were measured in 110 healthy post-menopausal women. Patients with secondary causes of osteoporosis were excluded. Results: Osteoporosis was diagnosed in 30 (27%) women and osteopenia in 54 (49%). Serum leptin concentrations were positively correlated with both lumbar spine (r = 0.343, p < 0.01) and femoral neck BMD (r = 0.370, p < 0.01). Adiponectin concentrations were negatively associated with BMD at both sites (r = −0.321, p < 0.01 and r = −0.448, p < 0.01 respectively). No significant correlation between ghrelin concentrations and BMD was found. Osteoporotic women had lower body weight, body mass index (BMI) and leptin concentrations, but higher adiponectin concentrations compared with non-osteoporotic women. In multivariate stepwise regression analysis, the association of adiponectin concentrations with BMD remained significant only for femoral neck, after adjustment for body weight or BMI. Conclusions: An inverse association between adiponectin and femoral neck BMD was found in post-menopausal women, independently of body weight. The positive association between leptin and BMD was dependent on body weight, whereas no effect of ghrelin on BMD was evident.