Circulating vitamin D concentration and age-related macular degeneration: Systematic review and meta-analysis. (June 2016)

• Record Type: Journal Article
• Authors: Annweiler, Cedric; Drouet, Morgane; Duval, Guillaume T; Paré, Pierre-Yves; Leruez, Stephanie; Dinomais, Mickael; Milea, Dan
• Is Part Of: Maturitas. Volume 88(2016)
• Page Start: 101
• Page End: 112
• Publication Date: 2016-06
• Subjects: Eye -- Age-related macular degeneration -- Meta-analysis -- Neuroendocrinology -- Vitamin D -- Older adults; Climacteric -- Periodicals; Menopause -- Periodicals; Climacteric -- Periodicals; Geriatrics -- Periodicals; Menopause -- Periodicals; Middle Aged -- Periodicals; Climatère -- Périodiques; Ménopause -- Périodiques; Climacterium; Climacteric; Menopause; Electronic journals; Periodicals; 612.66
• DOI: 10.1016/j.maturitas.2016.04.002
• Languages: English
• ISSNs: 0378-5122

Abstract

Highlights: Vitamin D may be involved in ocular health and function. High concentrations 25-hydroxyvitamin D are associated with less age-related macular degeneration. Concentrations of 25-hydroxyvitamin D under 50 nmol/L are associated with late-stage age-related macular degeneration. These findings provide a scientific basis for vitamin D replacement trials. Abstract: Vitamin D may be involved in ocular function in older adults, but there is no current consensus on a possible association between circulating concentrations of 25-hydroxyvitamin D (25OHD) and the occurrence of age-related macular degeneration (AMD). Our objective was to systematically review and quantitatively assess the association of circulating 25OHD concentration with AMD. A Medline search was conducted in November 2015, with no date limit, using the MeSH terms "Vitamin D" OR "Vitamin D deficiency" OR "Ergocalciferols" OR 'Cholecalciferol' combined with "Age-related macular degeneration" OR "Macular degeneration" OR "Retinal degeneration" OR "Macula lutea" OR "Retina". Fixed and random-effects meta-analyses were performed to compute (i) standard mean difference in 25OHD concentration between AMD and non-AMD patients; (ii) AMD risk according to circulating 25OHD concentration. Of the 243 retrieved studies, 11 observational studies—10 cross-sectional studies and 1 cohort study—met the selection criteria. The number of participants ranged from 65 to 17, 045 (52–100% women), and the number with AMD ranged from 31 to 1440. Circulating 25OHD concentration was 15% lower in AMD compared with non-AMD on average. AMD was inversely associated with the highest 25OHD quintile compared with the lowest (summary odds ratio (OR) = 0.83 [95%CI:0.71–0.97]), notably late AMD (summary OR = 0.47 [95%CI:0.28–0.79]). Circulating 25OHD < 50 nmol/L was also associated with late-stage AMD (summary OR = 2.18 [95%CI:1.34–3.56]), an association that did not persist when all categories of AMD were considered (summary OR = 1.26 [95%CI:0.90–1.76]). In conclusion, this meta-analysis provides evidence that high 25OHD concentrations may be protective against AMD, and that 25OHD concentrations below 50 nmol/L are associated with late AMD.