Frontispiece: Mutual Cooperation in the Formal Allyl Alcohol Nucleophilic Substitution and Hydration of Alkynes for the Construction of γ‐Substituted Ketones. Issue 19 (21st April 2016)

• Record Type: Journal Article
• Authors: Huang, Kaimeng; Wang, Hongkai; Liu, Lingyan; Chang, Weixing; Li, Jing
• Is Part Of: Chemistry. Volume 22:Issue 19(2016)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2016-04-21
• Subjects: 1, 5-enynols -- cyclization -- gold catalysis -- hydration -- nucleophilic substitution -- ring-opening reactions; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201681961
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract : Ring‐Opening Reactions Mutual‐cooperation of the formal allyl alcohol direct nucleophilic substitution reaction and highly regioselective hydration of internal alkynes was realized in one pot. A dihydrofuran intermediate was formed through intramolecular O−H insertion cyclization of alkyne activated by gold catalyst, and thus the C−O bond of allyl alcohol was weakened and simultaneously the regioselective hydration of internal alkyne was directed, resulting in the γ‐functionalized ketones. The full story can be found in the Communication by L. Liu, J. Li and colleagues onpage 6458 ff.