Hepatocyte nuclear factor 1 beta induces transformation and epithelial‐to‐mesenchymal transition. Issue 8 (31st March 2016)

• Record Type: Journal Article
• Authors: Matsui, Atsuka; Fujimoto, Jiro; Ishikawa, Kosuke; Ito, Emi; Goshima, Naoki; Watanabe, Shinya; Semba, Kentaro
• Is Part Of: FEBS letters. Volume 590:Issue 8(2016)
• Page Start: 1211
• Page End: 1221
• Publication Date: 2016-03-31
• Subjects: breast tumor -- epithelial‐to‐mesenchymal transition -- gene amplification -- hepatocyte nuclear factor 1 beta -- three‐dimensional culture; Biochemistry -- Periodicals; Biophysics -- Periodicals; Molecular biology -- Periodicals; Biochimie -- Périodiques; Biochemistry; Biophysics; Molecular biology; Periodicals; 572.05
• DOI: 10.1002/1873-3468.12147
• Languages: English
• ISSNs: 0014-5793

Abstract

Abstract : Gene amplification can be a cause of cancer, and driver oncogenes have been often identified in amplified regions. However, comprehensive analysis of other genes coamplified with an oncogene is rarely performed. We focused on the 17q12–21 amplicon, which contains ERBB2 . We established a screening system for oncogenic activity with the NMuMG epithelial cell line. We identified a homeobox gene, HNF1B, as a novel cooperative transforming gene. HNF1B induced cancerous phenotypes, which were enhanced by the coexpression of ERBB2, and induced epithelial‐to‐mesenchymal transition and invasive phenotypes. These results suggest that HNF1B is a novel oncogene that can work cooperatively with ERBB2 . Abstract :