HLA-B27 and Clinical Features of Acute Anterior Uveitis in Cuba†. (19th December 2012)

• Record Type: Journal Article
• Authors: Torres, Sylvia; Borges, Sandra; Artiles, Adriana
• Is Part Of: Ocular immunology and inflammation. Volume 21:Number 2(2013)
• Page Start: 119
• Page End: 123
• Publication Date: 2012-12-19
• Subjects: Acute anterior uveitis -- clinical features -- Cuban patients -- HLA-B27 allele -- ocular complications; Eye -- Diseases -- Immunological aspects -- Periodicals; Eye -- Inflammation -- Periodicals; 617.7
• DOI: 10.3109/09273948.2012.748080
• Languages: English
• ISSNs: 0927-3948

Abstract

Abstract: Background : There are few data about the epidemiology of acute anterior uveitis (AAU) from Latin America. In Cuba, the genetic admixture of the population could modify the HLA-B27-AAU association. In this study, the authors compared the distribution of the HLA-B27 allele in patients and controls and described some clinical outcomes. Materials and Methods : The clinical features of patients were collected from their medical records. HLA-B27 genotyping was performed using the polymerase chain reaction. HLA-B27 allele distribution was compared between patients and controls. Results : HLA-B27 allele was present in 55.4% of the patients and 0.87% of the controls. AAU HLA-B27 positivity was associated with males, frequent episodes, and a systemic disease. There is no difference in ocular complications between HLA-B27-positive and -negative patients. Conclusions : Results from this study are similar to data described in other countries. HLA-B27 allele distribution in controls is lower than other reports in Caucasian populations.