Intravenous iron sucrose versus oral iron ferrous sulfate for antenatal and postpartum iron deficiency anemia: a randomized trial. (12th December 2012)

• Record Type: Journal Article
• Authors: Froessler, Bernd; Cocchiaro, Carmel; Saadat-Gilani, Khaschayar; Hodyl, Nicolette; Dekker, Gustaaf
• Is Part Of: Journal of maternal-fetal & neonatal medicine. Volume 26:Number 7(2013:Jul.)
• Page Start: 654
• Page End: 659
• Publication Date: 2012-12-12
• Subjects: Intravenous iron -- oral iron -- peripartum iron deficiency anemia -- pregnancy -- red blood cell transfusion; Obstetrics -- Periodicals; Perinatology -- Periodicals; Infants (Newborn) -- Diseases -- Periodicals; Neonatology -- Periodicals; 618.2
• DOI: 10.3109/14767058.2012.746299
• Languages: English
• ISSNs: 1476-7058

Abstract

Abstract: Objective: To compare oral iron to intravenous iron administration to women in late pregnancy and/or after labor to correct iron deficiency. Methods: 271 anemic women (148 pregnant women and 123 women post lower segment caesarean section) with hemoglobin (Hb) levels below 110 g/L were enrolled over a two-year period and randomized to receive either two tablets FGF (ferrous sulfate with folic acid) or 400 mg of intravenous iron sucrose plus folic acid 600 µg. Treatment effectiveness was assessed by measuring Hb and ferritin postpartum on day 1, day 14 and day 42. Transfusions of red blood cells and adverse drug reactions were recorded. Results: Data of 214 women were available for analysis. Both forms of iron replacement therapy led to increased hemoglobin and ferritin levels over the testing period. Ferritin was significantly higher in the i.v. iron treatment group compared to the oral iron treatment group ( p = 0.004) two weeks after delivery, while Hb values did not differ between the groups. No serious adverse drug reactions were observed. Red blood cell transfusion rate was low (1.9%), with equal rates observed in both treatment groups. Conclusion: Intravenous and oral irons were both effective in correcting peripartum anemia, although intravenous iron restored stores faster than oral iron.