Environmental layout complexity affects neural activity during navigation in humans. (17th March 2016)

• Record Type: Journal Article
• Authors: Slone, Edward; Burles, Ford; Iaria, Giuseppe
• Editors: Foxe, John
• Is Part Of: European journal of neuroscience. Volume 43:Number 9(2016:May)
• Page Start: 1146
• Page End: 1155
• Publication Date: 2016-03-17
• Subjects: environmental neuroscience -- functional magnetic resonance imaging -- navigation -- spatial memory -- virtual environments; Nervous system -- Periodicals; 612.8
• DOI: 10.1111/ejn.13218
• Languages: English
• ISSNs: 0953-816X

Abstract

Abstract: Navigating large‐scale surroundings is a fundamental ability. In humans, it is commonly assumed that navigational performance is affected by individual differences, such as age, sex, and cognitive strategies adopted for orientation. We recently showed that the layout of the environment itself also influences how well people are able to find their way within it, yet it remains unclear whether differences in environmental complexity are associated with changes in brain activity during navigation. We used functional magnetic resonance imaging to investigate how the brain responds to a change in environmental complexity by asking participants to perform a navigation task in two large‐scale virtual environments that differed solely in interconnection density, a measure of complexity defined as the average number of directional choices at decision points. The results showed that navigation in the simpler, less interconnected environment was faster and more accurate relative to the complex environment, and such performance was associated with increased activity in a number of brain areas (i.e. precuneus, retrosplenial cortex, and hippocampus) known to be involved in mental imagery, navigation, and memory. These findings provide novel evidence that environmental complexity not only affects navigational behaviour, but also modulates activity in brain regions that are important for successful orientation and navigation. Abstract : Participants were asked to perform a navigation task in a simple and a complex virtual environment while undergoing functional MRI. Navigation in the simple environment was associated with increased neural activity relative to navigation in the complex environment in a number of brain regions important for navigation and memory, including the retrosplenial cortex, precuneus, dorsolateral prefrontal cortex, and hippocampus.