Synthesis of Novel Drug‐Like Small Molecules Based on Quinoxaline Containing Amino Substitution at C‐2. (30th July 2015)

• Record Type: Journal Article
• Authors: Rao, K. Raghavendra; Raghunadh, Akula; Mekala, Ramamohan; Meruva, Suresh Babu; Ganesh, K. Ravi; Krishna, T.; Kalita, Dipak; Laxminarayana, Eppakayala; Pal, Manojit
• Is Part Of: Journal of heterocyclic chemistry. Volume 53:Number 3(2016:May)
• Page Start: 901
• Page End: 908
• Publication Date: 2015-07-30
• Subjects: Heterocyclic compounds -- Periodicals; 547.59
• DOI: 10.1002/jhet.2177
• Languages: English
• ISSNs: 0022-152X

Abstract

Abstract : A series of novel "drug‐like" small molecules based on quinoxaline containing amino substitution at C‐2 were synthesized. All these molecules were prepared either via the reaction of 2‐phenyl‐3‐(piperazin‐1‐yl)quinoxaline with acyl bromides or benzyl bromides or variouscarboxylic acids or via the reaction of 2‐chloro‐3‐phenylquinoxaline with various amines. The structures of these novel compounds were confirmed by spectral analysis. The strategy used is simple and efficient and afforded good yields of quinoxaline derivatives. Abstract :