Nickel-catalyzed direct alkynylation of C(sp2)–H bonds of amides: an "inverse Sonogashira strategy" to ortho-alkynylbenzoic acids. Issue 6 (11th November 2015)

• Record Type: Journal Article
• Authors: Landge, Vinod G.; Shewale, Chinmay H.; Jaiswal, Garima; Sahoo, Manoj K.; Midya, Siba P.; Balaraman, Ekambaram
• Is Part Of: Catalysis science & technology. Volume 6:Issue 6(2016)
• Page Start: 1946
• Page End: 1951
• Publication Date: 2015-11-11
• Subjects: Catalysis -- Periodicals; 541.395
• DOI: 10.1039/c5cy01299f
• Languages: English
• ISSNs: 2044-4753

Abstract

Abstract : Nickel-catalyzed direct alkynylation of C(sp 2 )–H bonds of amides using commercially available, inexpensive 8-aminoquinoline as a removable bidentate directing group is described. Abstract : Nickel-catalyzed direct alkynylation of C(sp 2 )–H bonds of amides using commercially available, inexpensive 8-aminoquinoline as a removable bidentate directing group is described. The present ortho -alkynylation has a broad substrate scope, functional group tolerance and high regiocontrol, and can be scaled up. The efficiency and selectivity of this strategy provide sustainable routes to a diverse array of ortho -alkynylbenzoic acids under Ni(ii )-catalyzed conditions.