Microstructures: Mechanisms and Microenvironment Investigation of Cellularized High Density Gradient Collagen Matrices via Densification (Adv. Funct. Mater. 16/2016). (April 2016)

• Record Type: Journal Article
• Authors: Novak, Tyler; Seelbinder, Benjamin; Twitchell, Celina M.; van Donkelaar, Corrinus C.; Voytik‐Harbin, Sherry L.; Neu, Corey P.
• Is Part Of: Advanced functional materials. Volume 26:Number 16(2016)
• Page Start: 2772
• Page End: 2772
• Publication Date: 2016-04
• Subjects: 3D microenvironment -- chondrocyte phenotype and dedifferentiation -- molecular crowding -- physical gradient scaffold -- plastic compression; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adfm.201670103
• Languages: English
• ISSNs: 1616-301X

Abstract

Abstract : Biomaterials often have characteristic spatial gradients in physical properties that lead to specialized function. On page 2617, C. P. Neu and co‐workers form gradient matrices of natural biopolymers using a densification process that exudes fluid from the structure, leading to a reproducible reorganization of collagen and embedded cells. High‐density regions show increased fibril packing, mechanical properties, and fibril thickness, on par with values observed in native tissues like articular cartilage.