Histiocytosis with mixed cell populations. (4th April 2016)

• Record Type: Journal Article
• Authors: Martín, José M.; Jordá, Esperanza; Martín‐Gorgojo, Alejandro; Beteta, Gerardo; Monteagudo, Carlos
• Is Part Of: Journal of cutaneous pathology. Volume 43:Number 5(2016)
• Page Start: 456
• Page End: 460
• Publication Date: 2016-04-04
• Subjects: histiocytosis -- histopathology -- indeterminate cell histiocytosis -- juvenile xantogranuloma -- langerhans cell histiocytosis; Skin -- Diseases -- Periodicals; Dermatology -- Periodicals; 616
• DOI: 10.1111/cup.12687
• Languages: English
• ISSNs: 0303-6987

Abstract

Abstract : Langerhans cell histiocytosis (LCH) and juvenile xanthogranuloma (JXG) are thought to originate from a common stem cell precursor, with divergent differentiation under different microenvironmental conditions. We describe an exceptional case of multiple cutaneous lesions in a 10‐year‐old boy, in which the coexistence of both LCH and JXG cell populations is found in every single lesion. The presence of Birbeck granules and CD207 (langerin) immunostaining in the LCH component would argue against the diagnosis of indeterminate cell histiocytosis (ICH). This unique case gives additional support to the hypothesis of a potentially common histogenesis for LCH and JXG.