Human papillomavirus infection in male patients with STI‐related symptoms in Hanoi, Vietnam. Issue 6 (19th November 2015)

• Record Type: Journal Article
• Authors: Le, Hai Ha Long; Bi, Xiuqiong; Ishizaki, Azumi; Van Le, Hung; Nguyen, Trung Vu; Hosaka, Norimitsu; Ichimura, Hiroshi
• Is Part Of: Journal of medical virology. Volume 88:Issue 6(2016)
• Page Start: 1059
• Page End: 1066
• Publication Date: 2015-11-19
• Subjects: HPV -- STI -- male -- Vietnam; Virology -- Periodicals; 616
• DOI: 10.1002/jmv.24422
• Languages: English
• ISSNs: 0146-6615

Abstract

Abstract : This cross‐sectional study investigated the prevalence, genotypes, and risk factors for human papillomavirus (HPV) infection in Hanoi, Vietnam. The study included 192 males (mean age, 32.9 years) with symptoms related to sexually transmitted infections (STI). Urinary, penile, and urethral samples were collected in April and May, 2014. HPV DNA was detected with PCR, performed with modified and/or original GP5 + /GP6 + primers. HPV genotypes were determined with a gene array assay. Neisseria gonorrhoeae (NG) and Chlamydia trachomatis (CT) DNA were detected with loop‐mediated isothermal amplification. HPV DNA, NG, and CT were detected in 48 (25.0%), 23 (12.0%), and 41 (21.4%) patients, respectively. HPV DNA appeared in penile samples (21.0%, 39/186) more frequently than in urinary (3.1%, 6/191, P < 0.001) and urethral (9.4%, 18/192, P = 0.002) samples. Among patients with HPV, genotype prevalence was: HPV81 (22.9%), HPV52 (18.8%), HPV18 (16.7%), and HPV16 (6.3%). Multiple‐type and high risk‐type HPV infections were determined in 33.3% and 64.6%, respectively. Multivariate analysis showed a significant association of HPV infection in urethra with younger sexual debut age. HPV52 was the most prevalent high‐risk HPV genotype, whereas HPV16 was less common in the male Vietnamese patients with STI‐related symptoms. Younger sexual‐debut age was a risk factor for HPV infection in urethra. J. Med. Virol. 88:1059–1066, 2016 . © 2015 Wiley Periodicals, Inc.