A self-adjusted weighted likelihood ratio test for global clustering of disease. Issue 5 (23rd March 2016)

• Record Type: Journal Article
• Authors: Shu, Lianjie; Zhou, Ruoyu; Su, Yan
• Is Part Of: Journal of statistical computation and simulation. Volume 86:Issue 5(2016)
• Page Start: 996
• Page End: 1009
• Publication Date: 2016-03-23
• Subjects: likelihood ratio -- weighted function -- global chain clustering -- hot-spot clusters; Mathematical statistics -- Data processing -- Periodicals; Digital computer simulation -- Periodicals; 519.5028505
• DOI: 10.1080/00949655.2015.1049604
• Languages: English
• ISSNs: 0094-9655

Abstract

Abstract : Compared to tests for localized clusters, the tests for global clustering only collect evidence for clustering throughout the study region without evaluating the statistical significance of the individual clusters. The weighted likelihood ratio (WLR) test based on the weighted sum of likelihood ratios represents an important class of tests for global clustering. Song and Kulldorff (Likelihood based tests for spatial randomness. Stat Med. 2006;25(5):825–839) developed a wide variety of weight functions with the WLR test for global clustering. However, these weight functions are often defined based on the cell population size or the geographic information such as area size and distance between cells. They do not make use of the information from the observed count, although the likelihood ratio of a potential cluster depends on both the observed count and its population size. In this paper, we develop a self-adjusted weight function to directly allocate weights onto the likelihood ratios according to their values. The power of the test was evaluated and compared with existing methods based on a benchmark data set. The comparison results favour the suggested test especially under global chain clustering models.