Determination of the least amount of iodine load required for the detection of pancreatic adenocarcinoma at 80-kVp CT. Issue 5 (May 2016)

• Record Type: Journal Article
• Authors: Noda, Yoshifumi; Goshima, Satoshi; Miyoshi, Toshiharu; Watanabe, Haruo; Kawada, Hiroshi; Kawai, Nobuyuki; Koyasu, Hiromi; Kanematsu, Masayuki; Matsuo, Masayuki; T Bae, Kyongtae
• Is Part Of: European journal of radiology. Volume 85:Issue 5(2016)
• Page Start: 901
• Page End: 905
• Publication Date: 2016-05
• Subjects: Pancreas -- CT -- Pancreatic adenocarcinoma -- Contrast -- 80 kVp; Medical radiology -- Periodicals; Radiology -- Periodicals; Radiologie médicale -- Périodiques; Medical radiology; Periodicals; 616.075705
• DOI: 10.1016/j.ejrad.2016.02.014
• Languages: English
• ISSNs: 0720-048X

Abstract

Abstract: Purpose: To determine the iodine load per body weight (ILPBW) that is minimally required for the detection of pancreatic adenocarcinoma for 80 kVp CT imaging. Material and methods: Institutional review board approval and written informed consent were obtained. Fifty-seven consecutive patients with histopathologically-proven pancreatic adenocarcinoma were assigned to three groups at random according to iodine load (0.5, 0.4, and 0.3 gI/kg) and underwent CT at 80 kVp. Enhancement of the pancreas and visualization of the tumor were assessed during the pancreatic parenchymal-phase and compared among the three groups. The relationship between the iodine load and tumor conspicuity was also analyzed. Results: The mean CT number of the pancreas (HUpancreas ) was higher in the 0.5 gI/kg group (158.8HU) than in the 0.4 (121.7HU) and 0.3 (106.6HU) gI/kg groups ( P < 0.05). Tumor-to-pancreas contrast (HUtumor-to-pancreas ) was also higher in 0.5 gI/kg group (88.9HU) than in 0.4 (62.2HU) and 0.3 (54.5HU) gI/kg groups ( P < 0.05). Linear regression between HUpancreas or HUtumor-to-pancreas and ILPBW were expressed as HUpancreas = 23.3 + 263.9 × ILPBW ( r = 0.74, P < 0.0001) and HUtumor-to-pancreas = −1.24 + 174.3 × ILPBW ( r = 0.56, P < 0.0001), respectively. The iodine load estimated to achieve an acceptable HUpancreas (>100HU) and HUtumor-to-pancreas (>50HU) were 0.29 and 0.30 gI/kg, respectively. Conclusion: An iodine load of 0.3 gI/kg was the least amount required for the detection of pancreatic adenocarcinoma at 80 kVp CT.