MRI Measurements of Iron Load in Transfusion‐Dependent Patients: Implementation, Challenges, and Pitfalls. Issue 5 (29th December 2015)

• Record Type: Journal Article
• Authors: Quinn, Charles T.; St Pierre, Tim G.
• Is Part Of: Pediatric blood & cancer. Volume 63:Issue 5(2016:)
• Page Start: 773
• Page End: 780
• Publication Date: 2015-12-29
• Subjects: anemia -- iron overload -- magnetic resonance imaging -- sickle cell disease -- thalassemia -- transfusion; Tumors in children -- Periodicals; Blood -- Diseases -- Periodicals; Cancer in children -- Periodicals; 618.92
• DOI: 10.1002/pbc.25882
• Languages: English
• ISSNs: 1545-5009

Abstract

Abstract : Magnetic resonance imaging (MRI) has played a key role in studies of iron overload in transfusion‐dependent patients, providing insights into the relations among liver and cardiac iron loading, iron chelator dose, and morbidity. Currently, there is rapid uptake of these methods into routine clinical practice as part of the management strategy for iron overload in regularly transfused patients. Given the manifold methods of data acquisition and analysis, there are several potential pitfalls that may result in inappropriate decision making. Herein, we review the challenges of establishing suitable MRI techniques for tissue iron measurement in regularly transfused patients.