Pediatric B‐Cell Lymphoma With Lymphoblastic Morphology, TdT Expression, MYC Rearrangement, and Features Overlapping With Burkitt Lymphoma. Issue 5 (19th January 2016)

• Record Type: Journal Article
• Authors: Meznarich, Jessica; Miles, Rodney; Paxton, Christian N.; Afify, Zeinab
• Is Part Of: Pediatric blood & cancer. Volume 63:Issue 5(2016:)
• Page Start: 938
• Page End: 940
• Publication Date: 2016-01-19
• Subjects: B‐lymphoblastic lymphoma -- Burkitt lymphoma -- MYC rearrangement; Tumors in children -- Periodicals; Blood -- Diseases -- Periodicals; Cancer in children -- Periodicals; 618.92
• DOI: 10.1002/pbc.25907
• Languages: English
• ISSNs: 1545-5009

Abstract

Abstract : Burkitt lymphoma (BL) and B‐lymphoblastic lymphoma are subtypes of pediatric non‐Hodgkin lymphoma with different presenting features, treatment, and outcomes. This case report documents a 5‐year‐old female who presented with B‐cell lymphoma with lymphoblastic morphology, terminal deoxynucleotidyl transferase expression, MYC rearrangement, and features overlapping with BL. Genomic microarray analysis identified a gain on the long arm of chromosome 1 without other definitive changes. She was treated according to a BL protocol and remains in remission 16‐months after initial diagnosis.