Characterization and correction of pressure drift in the ManoScan™ high‐resolution manometry system: In vitro and in vivo. Issue 5 (3rd February 2016)

• Record Type: Journal Article
• Authors: Lamvik, K.; Guiu Hernandez, E.; Jones, R.; Huckabee, M.‐L.
• Is Part Of: Neurogastroenterology & motility. Volume 28:Issue 5(2016)
• Page Start: 732
• Page End: 742
• Publication Date: 2016-02-03
• Subjects: drift -- high‐resolution manometry -- ManoScan™ -- measurement error -- pharyngeal manometry; Gastrointestinal system -- Motility -- Periodicals; Gastrointestinal system -- Innervation -- Periodicals; 616.33
• DOI: 10.1111/nmo.12770
• Languages: English
• ISSNs: 1350-1925

Abstract

Abstract: Background: A substantial pressure drift in high‐resolution manometry (HRM) has been reported; however, fundamental questions remain regarding the origin and management of this drift. The aim of this study was to provide critical in‐depth analyses of ManoScan ™ HRM drift in vitro and in vivo . Methods: A total of sixteen 15‐min studies and twelve 5‐h studies were performed in a water bath at 37 °C at 4.0 cm depth (2.9 mmHg) with ESO and ESO Z catheters. Six 5‐h in vitro studies were performed similarly at a depth of 9.0 cm (6.6 mmHg). Eight 15‐min studies and nine 8‐h in vivo studies were performed with healthy participants. Two correction methods – thermal compensation (TC) and interpolated thermal compensation (ITC) – were tested. Key Results: Overall pressure drift varied both between studies ( p < 0.01) and within sensors ( p < 0.01). Drift resulted from thermal shock, an initial pressure change at intubation, and baseline drift, a linear drift over time ( R 2 > 0.96). Contrary to previous reports, there was no correlation between drift and average ( r = −0.02) or maximum pressure exposure ( r = −0.05). Following data correction, ITC had the lowest median error but persisted with a maximum error of 2.5 mmHg (IQR = 3.0). Conclusions & Inferences: The substantial drift in the ManoScan ™ HRM system is highly variable and not corrected via the standard operating instructions. ITC has superior performance but requires communication with the manufacturer to enable this option. This has a substantial impact on clinical diagnosis, utility of existing normative data, and future research of HRM. Abstract : The aim of this study was to provide critical in‐depth analyses of ManoScan ™ high‐resolution manometry pressure drift in vitro and in vivo . Results indicate that the substantial drift in the ManoScan ™ HRM system is highly variable and not corrected via the standard operating instructions.