Modeling repetitive, non‐globular proteins. (16th March 2016)

• Record Type: Journal Article
• Authors: Basu, Koli; Campbell, Robert L.; Guo, Shuaiqi; Sun, Tianjun; Davies, Peter L.
• Is Part Of: Protein science. Volume 25:Number 5(2016:May)
• Page Start: 946
• Page End: 958
• Publication Date: 2016-03-16
• Subjects: protein modeling -- repetitive protein -- antifreeze protein -- Beta‐solenoid -- tandem repeat -- molecular dynamics; Proteins -- Periodicals; 572.6
• DOI: 10.1002/pro.2907
• Languages: English
• ISSNs: 0961-8368

Abstract

Abstract: While ab initio modeling of protein structures is not routine, certain types of proteins are more straightforward to model than others. Proteins with short repetitive sequences typically exhibit repetitive structures. These repetitive sequences can be more amenable to modeling if some information is known about the predominant secondary structure or other key features of the protein sequence. We have successfully built models of a number of repetitive structures with novel folds using knowledge of the consensus sequence within the sequence repeat and an understanding of the likely secondary structures that these may adopt. Our methods for achieving this success are reviewed here.