The importance of surgical margins in primary malignancies of the liver. Issue 3 (10th December 2015)

• Record Type: Journal Article
• Authors: Lafaro, Kelly; Grandhi, Miral Sadaria; Herman, Joseph M.; Pawlik, Timothy M.
• Other Names: Kooby David A. guestEditor.; Maithel Shishir K. guestEditor.
• Is Part Of: Journal of surgical oncology. Volume 113:Issue 3(2016)
• Page Start: 296
• Page End: 303
• Publication Date: 2015-12-10
• Subjects: liver cancer -- surgical margins -- hepatocellular carcinoma -- intrahepatic cholangiocarcinoma; Cancer -- Surgery -- Periodicals; Neoplasms -- Periodicals; 616
• DOI: 10.1002/jso.24123
• Languages: English
• ISSNs: 0022-4790

Abstract

Abstract : Resection is an important treatment modality for hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). Anatomic resection is generally preferred for HCC. When anatomic resection is not feasible, prospective data have demonstrated an improved outcome among HCC patients who have a resection with wide versus narrow surgical margins. Similarly, among patients with ICC, R1 resection has been associated with worse outcomes. In addition, margin width may also impact risk of recurrence and survival. As such, provided adequate functional liver remnant remains, anatomic resection with wide margins is recommended for HCC and ICC. J. Surg. Oncol. 2016;113:296–303 . © 2015 Wiley Periodicals, Inc.