ChemInform Abstract: A Highly Enantioselective Biginelli Reaction Using Self‐Assembled Methanoproline—Thiourea Organocatalysts: Asymmetric Synthesis of 6‐Isopropyl‐3, 4‐dihydropyrimidines. Issue 17 (April 2016)

• Record Type: Journal Article
• Authors: Hang, Zhijun; Zhu, Jun; Lian, Xiang; Xu, Peng; Yu, Han; Han, Sheng
• Is Part Of: ChemInform. Volume 47:Issue 17(2016)
• Page Start: no
• Page End: no
• Publication Date: 2016-04
• Subjects: pyrimidine derivatives -- multicomponent reactions -- ring closure reactions, annulation reactions -- organocatalysis -- diastereoselective syntheses, enantioselective syntheses (incl. cis/trans‐isomerism); Chemistry -- Abstracts -- Periodicals; 540.5
• DOI: 10.1002/chin.201617174
• Languages: English
• ISSNs: 0931-7597

Abstract

Abstract: The three‐component reaction of thiourea, aldehydes, and ketoester (III) allows the synthesis of a wide range of pyrimidine derivatives in high yields with excellent enantioselectivities.