A new kaurane diterpenoid from Isodon inflexus. Issue 9 (2nd May 2016)

• Record Type: Journal Article
• Authors: Xu, Guang-Hua; Cai, Xing-Fu; Jin, Xuejun; Lee, Jung Joon
• Is Part Of: Natural product research. Volume 30:Issue 9(2016)
• Page Start: 995
• Page End: 1000
• Publication Date: 2016-05-02
• Subjects: Isodon inflexus -- kaurane diterpenoid -- structure elucidation -- NF-κB; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2015.1094803
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: A new 7, 20-epoxy kaurane diterpenoid, 15-acetyldemethylkamebacetal A (1 ) and six known kaurane diterpenoids (2 –7 ) were isolated from the aerial parts of Isodon inflexus in nuclear transcription factor-κB (NF-κB)-dependent reporter gene assay-guided fractionation. Their chemical structures were determined on the basis of extensive spectroscopic analysis (UV, IR, MS, 1D- and 2D-NMR) and comparison with literature data. The isolated compounds were evaluated for their inhibitory effects on TNF- α -induced NF-κB activation, and all compounds exhibited NF-κB inhibitory activities with IC50 values ranging from 1.91 to 20.15 μM. Abstract :