Mass spectrometry-guided isolation of two new benzoquinoline alkaloids from Macleaya cordata. Issue 9 (2nd May 2016)

• Record Type: Journal Article
• Authors: Qing, Zhi-Xing; Xu, Yu-Qin; Yang, Peng; Yu, Kun; Cheng, Pi; Zeng, Jian-Guo
• Is Part Of: Natural product research. Volume 30:Issue 9(2016)
• Page Start: 1030
• Page End: 1035
• Publication Date: 2016-05-02
• Subjects: Macleaya cordata -- benzoquinoline alkaloids -- mass spectrometry-guided isolation -- 2, 3-methylenedioxy-7, 10- dimethyl-7, 8, 9, 10-tetrahydrobenzoquinoline -- 2, 3-methylenedioxy-7, 10-dimethyl-8-carboxyl-benzoquinoline; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2015.1101695
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Two new alkaloids, named 2, 3-methylenedioxy-7, 10-dimethyl-7, 8, 9, 10-tetrahydro-benzoquinoline (1 ) and 2, 3-methylenedioxy-7, 10-dimethyl-8-carboxyl-benzoquinoline (2 ), were detected primarily from the fruits of Macleaya cordata by their different fragmentation pathways. And then isolation of the two compounds was performed by column chromatography and preparative HPLC under the guiding of mass spectrometry. Finally, their structures were determined by spectroscopic analysis. Graphical abstract: