A new bioactive steroidal ketone from the South China Sea sponge Xestospongia testudinaria. Issue 2 (1st February 2016)

• Record Type: Journal Article
• Authors: He, Wen-Fei; Xue, Duo-Qing; Yao, Li-Gong; Li, Jia; Liu, Hai-Li; Guo, Yue-Wei
• Is Part Of: Journal of Asian natural products research. Volume 18:Issue 2(2016)
• Page Start: 195
• Page End: 199
• Publication Date: 2016-02-01
• Subjects: Petrosiidae -- Xestospongia testudinaria -- sponge -- steroidal ketone -- PTP1B inhibitory activity; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2015.1056521
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract : A new steroidal ketone (1 ), with an ergosta-22, 25-diene side chain, was obtained from the South China Sea marine sponge Xestospongia testudinaria. The structure of1 was determined on the basis of detailed spectroscopic analysis and by comparison with literature. Compound1 exhibited significant inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), a key target for the treatment of type II diabetes and obesity, with an IC50 value of 4.27 ± 0.55 μM, which is comparable with the positive control oleanolic acid (IC50 = 2.63 ± 0.22 μM).