Two new γ-pyrone glucosides from Paeonia albiflora. Issue 2 (1st February 2016)

• Record Type: Journal Article
• Authors: Chen, Shao-Dan; Wang, Dong-Mei; Lu, Chuan-Jian; Zhao, Rui-Zhi
• Is Part Of: Journal of Asian natural products research. Volume 18:Issue 2(2016)
• Page Start: 153
• Page End: 158
• Publication Date: 2016-02-01
• Subjects: Paeonia albiflora -- γ-pyrone glucosides -- chemical constituents; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2015.1082548
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract : Two new γ-pyrone glucosides, along with three known compounds, were isolated from the roots of Paeonia albiflora, and their structures were elucidated by spectral experiments, chemical analysis, and comparison with literature data. The structures of the new compounds were established as 2-(hydroxymethyl)-4-oxo-4H-pyran-3-yl-6- O -α-L -rhamnopyranosyl-β-D -glucopyranoside (1 ), and 2-(hydroxymethyl)-4-oxo-4H-pyran-3-yl-6- O -galloyl-β-D -glucopyranoside (2 ). The inhibitory activity on the release of TNF-α of compounds1 –5 was evaluated in vitro . This is the first report of the presence of γ-pyrone glucoside in P. albiflora .