Homobimetallic zinc(II) dithiocarbamates: synthesis, characterization and in vivo antihyperglycemic activity. Issue 3 (1st February 2016) - Zia-ur-Rehman,
Abstract: This article presents structural characteristic and in vivo antihyperglycemic activities of three new homobimetallic Zn(II) dithiocarbamates (1 –3 ) with general formula [ZnL2 ]2, where L is 4-(3-methoxyphenyl)piperazine-1-carbodithioate (1 ), 4-(4-methoxyphenyl)piperazine-1-carbodithioate (2 ) and 4-benzhydrylpiperazine-1-carbodithiaoate (3 ). These complexes have been characterized by elemental analysis, FT-IR, multinuclear NMR ( 1 H and 13 C), and X-ray single crystal analysis. The latter technique has confirmed the homobimetallic nature of1 and2 in which Zn ions are linked via sulfurs to form a four-membered ring Zn2 S2 . Non-covalent intermolecular interactions give a supramolecular ladder-like zigzag chain (1 ) and layered structure (2 ). The antihyperglycemic activities revealed that the blood glucose lowering ability follows the trend: glibenclamide (83.0 mg dL −1 ) > 3 (97.6 mg dL −1 ) > 2 (100.4 mg dL −1 ) > 1 (141.4 mg dL −1 ). Abstract :