Timing of high-frequency cortical stimulation in a genetic absence model. (2nd June 2016)

• Record Type: Journal Article
• Authors: van Heukelum, S.; Kelderhuis, J.; Janssen, P.; van Luijtelaar, G.; Lüttjohann, A.
• Is Part Of: Neuroscience. Volume 324(2016)
• Page Start: 191
• Page End: 201
• Publication Date: 2016-06-02
• Subjects: DBS deep brain stimulation -- HFS high-frequency stimulation -- LTD long-term depression -- PCLS post-closed-loop stimulation -- PIR Passive-Infrared-Registration -- PYS post-yoked-stimulation -- SN subthalamic nucleus -- SWD spike-wave discharges; spike-wave discharges -- deep brain stimulation -- yoked control stimulation -- somatosensory cortex -- WAG/Rij rats -- neuroplasticity; Neurochemistry -- Periodicals; Neurophysiology -- Periodicals; Neurology -- Periodicals; Neurochimie -- Périodiques; Neurophysiologie -- Périodiques; Neurochemistry; Neurophysiology; Electronic journals; Periodicals; Electronic journals; 612.8
• DOI: 10.1016/j.neuroscience.2016.02.070
• Languages: English
• ISSNs: 0306-4522

Abstract

Highlights: Timing of high-frequency stimulation (HFS) determines acute and long-term effects. Cortical closed-loop HFS reliably disrupts SWD. Cortical closed-loop HFS reduces SWD number during and after stimulation. Yoked stimulation of cortex can induce epileptic afterdischarges. Abstract: Introduction: Seizure control is one of the ultimate aims of epileptology: here acute and prolonged effects of closed loop high-frequency stimulation of the somatosensory cortex on the expression of spontaneously occurring spike-wave discharges (SWD) were investigated in a genetic absence model. Effects of closed loop stimulation in the experimental group were compared with a yoked control group allowing to investigate the effect of timing related to SWD occurrence, while controlling for amount and intensity of stimulation. Methods: WAG/Rij rats were implanted with stimulation electrodes in the deep layers of the somatosensory cortex, and recording electrodes in the cortex and thalamus. Closed-loop and yoked stimulation (1 sec trains, biphasic 0.4 msec pulses, 130 Hz) sessions lasted 24 h. The stimulation sessions were preceded and followed by baseline and post stimulation 24-h recordings. Results: Closed-loop stimulation interrupted SWD and duration of SWD was shortened. Both types of stimulation resulted in a reduction in SWD number during stimulation sessions. Closed-loop stimulation also resulted in less SWD during the last eight hours of the post-stimulation recording session. Sometimes yoked stimulation induced low-frequency afterdischarges. Discussion: SWD can be aborted by closed-loop stimulation of the somatosensory cortex, and at the same time the number of SWD was reduced. It can be regarded as a relatively safe neuromodulatory technique without habituation. The reduction of SWD during yoked stimulation session might be caused by 3 Hz afterdischarges. The reduction of SWD on the stimulation and post-stimulation sessions demonstrates the critical relevance of timing for the induction of longer lasting neuromodulatory effects: it suggests that absence seizures themselves might be involved in their reoccurrence.