When Myc's asleep, embryonic stem cells are dormant. (11th March 2016)

• Record Type: Journal Article
• Authors: Nakagawa, Masato; Karagiannis, Peter; Yamanaka, Shinya
• Is Part Of: EMBO journal. Volume 35:Number 8(2016)
• Page Start: 801
• Page End: 802
• Publication Date: 2016-03-11
• Subjects: Molecular biology -- Periodicals; 572.805
• DOI: 10.15252/embj.201694095
• Languages: English
• ISSNs: 0261-4189

Abstract

Abstract : Myc is one of the original reprogramming factors used to produce induced pluripotent stem cells. However, it is not necessary, instead its main role is to increase the efficiency of the reprogramming. The article by Scognamiglio et al (2016 ) helps clarify how. The authors show that Myc depletion leads to a reversible dormant state consistent with diapause. In this state, the cell sees its proliferation potential diminished but its pluripotency unchanged. The ability to coordinate the induction of this state should have important implications in cell differentiation. Abstract : c‐Myc and N‐Myc are dispensable for the control of pluripotency in embryonic stem cells and diapause—a state of suspension during embryonic development, but control reversible entry and exit from dormancy by governing biosynthesis and metabolism.