Nanomedicine: Intercellular Transport of Nanomaterials is Mediated by Membrane Nanotubes In Vivo (Small 14/2016). Issue 14 (April 2016)

• Record Type: Journal Article
• Authors: Rehberg, Markus; Nekolla, Katharina; Sellner, Sabine; Praetner, Marc; Mildner, Karina; Zeuschner, Dagmar; Krombach, Fritz
• Is Part Of: Small. Volume 12:Issue 14(2016)
• Page Start: 1818
• Page End: 1818
• Publication Date: 2016-04
• Subjects: bioimaging -- in vivo distribution -- macrophages -- membrane nanotubes -- nanoparticles; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.201670068
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract : Cellular uptake of nanomaterials from the bloodstream and their subsequent distribution in tissue is a crucial step for diverse drug delivery approaches. On page 1882, M. Rehberg and co‐workers describe the presence of microtubule‐containing membrane nanotubes connecting perivascular and tissue‐resident macrophages in skeletal muscle tissue. Perivascular macrophages are able to sample nanoparticles from the blood stream, which are then actively transported in the muscle within membrane nanotubes.