An efficient one pot three‐component domino reaction for the synthesis of 1, 3, 4‐trisubstituted pyrroles. Issue 4 (4th April 2016)

• Record Type: Journal Article
• Authors: Kumar, Sundaravel Vivek; Muthusaravanan, Sivasubramanian; Muthusubramanian, Shanmugam; Perumal, Subbu
• Is Part Of: ChemistrySelect. Volume 1:Issue 4(2016)
• Page Start: 675
• Page End: 679
• Publication Date: 2016-04-04
• Subjects: Antifungal agent -- Metal free synthesis -- Multicomponent domino reaction -- Pyrroles; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.201600108
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: An efficient synthesis of 1, 3, 4‐trisubstituted pyrroles via three‐component domino reactions of (E)‐3‐(dimethylamino)‐1‐arylprop‐2‐en‐1‐ones, anilines and β‐nitrostyrenes in acetic acid is described. This one pot three‐component transformation presumably proceeds via addition–elimination/Michael addition/intramolecular annulation/elimination domino sequence of reactions with one C‐C and two C‐N bonds formation in a single synthetic operation. Additionally, this methodology has been applied to the formal synthesis of an antifungal agent as well. Abstract : An efficient synthesis of 1, 3, 4‐trisubstituted pyrroles via three‐component domino reactions of (E)‐3‐(dimethylamino)‐1‐arylprop‐2‐en‐1‐ones, anilines and β‐nitrostyrenes in acetic acid is described. This one pot three‐component transformation presumably proceeds via addition–elimination/Michael addition/intramolecular annulation/elimination domino sequence of reactions with one C‐C and two C‐N bonds formation in a single synthetic operation. Additionally, this methodology has been applied to the formal synthesis of an antifungal agent as well.