Flexible Octopus‐Shaped Hydrogel Particles for Specific Cell Capture. Issue 15 (1st March 2016)

• Record Type: Journal Article
• Authors: Chen, Lynna; An, Harry Z.; Haghgooie, Ramin; Shank, Aaron T.; Martel, Joseph M.; Toner, Mehmet; Doyle, Patrick S.
• Is Part Of: Small. Volume 12:Issue 15(2016)
• Page Start: 2001
• Page End: 2008
• Publication Date: 2016-03-01
• Subjects: cell capture -- circulating tumor cells -- hydrogels -- microfluidics -- microparticles; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.201600163
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract : Multiarm hydrogel microparticles with varying geometry are fabricated to specifically capture cells expressing epithelial cell adhesion molecule. Results show that particle shape influences cell‐capture efficiency due to differences in surface area, hydrodynamic effects, and steric constraints. These findings can lead to improved particle design for cell separation and diagnostic applications.