CAST your vote: is calpain inhibition the answer to ALS?. Issue 2 (23rd March 2016)

• Record Type: Journal Article
• Authors: Wright, Amanda L.; Vissel, Bryce
• Is Part Of: Journal of neurochemistry. Volume 137:Issue 2(2016)
• Page Start: 140
• Page End: 141
• Publication Date: 2016-03-23
• Subjects: Neurochemistry -- Periodicals; 616.8042
• DOI: 10.1111/jnc.13296
• Languages: English
• ISSNs: 0022-3042

Abstract

Abstract : A publication in the Journal of Neurochemistry by Rao et al . (2016) suggests that the overexpression of the calpain inhibitor, calpastatin (CAST) rescues neuron loss and increases survival of the amyotrophic lateral sclerosis (ALS) mouse model, hSOD1G93A. The findings of Rao et al . (2016) provide an insight into the mechanisms that lead to neuronal loss in ALS and suggest a cell loss pathway common to several neurodegenerative disorders that may be therapeutically targeted. Here, we highlight the findings of Rao et al . (2016) and discuss some key considerations required prior to assessing the potential use of calpain inhibitors in the clinic. Read the highlighted article ' Calpastatin inhibits motor neuron death and increases survival in hSOD1 G93A mice ' on page 253 . Abstract : A publication in the Journal of Neurochemistry by Rao et al . (2016) suggests that the overexpression of the calpain inhibitor, calpastatin (CAST) rescues neuron loss and increases survival of the amyotrophic lateral sclerosis (ALS) mouse model, hSOD1G93A. The findings of Rao et al . (2016) provide an insight into the mechanisms that lead to neuronal loss in ALS and suggest a cell loss pathway common to several neurodegenerative disorders that may be therapeutically targeted. Here, we highlight the findings of Rao et al . (2016) and discuss some key considerations required prior to assessing the potential use of calpain inhibitors in the clinic. Read the highlighted article ' Calpastatin inhibits motor neuron death and increases survival in hSOD1 G93A mice ' on page 253 .