Pd(ii)-catalyzed β-C–H arylation of O-methyl ketoximes with iodoarenes. Issue 3 (29th January 2016)

• Record Type: Journal Article
• Authors: Mu, Yucheng; Tan, Xiaodong; Zhang, Yemin; Jing, Xiaobi; Shi, Zhuangzhi
• Is Part Of: Organic chemistry frontiers. Volume 3:Issue 3(2016:Mar)
• Page Start: 380
• Page End: 384
• Publication Date: 2016-01-29
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/c5qo00438a
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : A Pd(ii )-catalyzed selective β-arylation of O -methyl ketoximes was developed using iodoarenes as the coupling partners. Abstract : A Pd(ii )-catalyzed selective β-arylation of O -methyl ketoximes was developed using iodoarenes as the coupling partners. This transformation has good functional group compatibility and can serve as a powerful synthetic tool for late-stage C–H arylation of complex compounds. Moreover, when employing 2-iodobenzoic acids as the substrates in this developed catalytic system, a type of unexpected five-membered lactones could be formed by tandem sp 3 C–H arylation and oxygenation.