Hyperpolarized 6Li as a probe for hemoglobin oxygenation level. (11th August 2015)

• Record Type: Journal Article
• Authors: Balzan, Riccardo; Mishkovsky, Mor; Simonenko, Yana; van Heeswijk, Ruud B.; Gruetter, Rolf; Eliav, Uzi; Navon, Gil; Comment, Arnaud
• Is Part Of: Contrast media & molecular imaging. Volume 11:Number 1(2016:Jan./Feb.)
• Page Start: 41
• Page End: 46
• Publication Date: 2015-08-11
• Subjects: lithium -- hyperpolarization -- dynamic nuclear polarization -- magnetic resonance -- MRI -- molecular imaging -- blood -- deoxyhemoglobin; Diagnostic imaging -- Periodicals; Magnetic resonance imaging -- Periodicals; Contrast media (Diagnostic imaging) -- Periodicals; Contrast Media -- Periodicals; Diagnostic Imaging -- Periodicals; Substances de contraste -- Périodiques; Diagnostics moléculaires -- Périodiques; Imagerie médicale; Substance de contraste; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.0754
• DOI: 10.1002/cmmi.1656
• Languages: English
• ISSNs: 1555-4309

Abstract

Abstract : Hyperpolarization by dissolution dynamic nuclear polarization (DNP) is a versatile technique to dramatically enhance the nuclear magnetic resonance (NMR) signal intensity of insensitive long‐ T 1 nuclear spins such as 6 Li. The 6 Li longitudinal relaxation of lithium ions in aqueous solutions strongly depends on the concentration of paramagnetic species, even if they are present in minute amounts. We herein demonstrate that blood oxygenation can be readily detected by taking advantage of the 6 Li signal enhancement provided by dissolution DNP, together with the more than 10% decrease in 6 Li longitudinal relaxation as a consequence of the presence of paramagnetic deoxyhemoglobin. Copyright © 2015 John Wiley & Sons, Ltd. Abstract : Effect of blood oxygenation on the longitudinal relaxation time of hyperpolarized 6 Li. Oxygenated hemoglobin being diamagnetic, it does not affect the 6 Li relaxation. In contrast, 6 Li T 1 is more than 10% shorter in the presence of deoxyhemoglobin because it is paramagnetic.