Association of polycyclic aromatic hydrocarbons in housewives' hair with hypertension. (June 2016)

• Record Type: Journal Article
• Authors: Wang, Bin; Li, Zhiwen; Ma, Yiqiu; Qiu, Xinghua; Ren, Aiguo
• Is Part Of: Chemosphere. Volume 153(2016)
• Page Start: 315
• Page End: 321
• Publication Date: 2016-06
• Subjects: Hypertension -- Polycyclic aromatic hydrocarbons -- PAHs -- Gene polymorphism -- SNPs; Pollution -- Periodicals; Pollution -- Physiological effect -- Periodicals; Environmental sciences -- Periodicals; Atmospheric chemistry -- Periodicals; 551.511
• DOI: 10.1016/j.chemosphere.2016.03.067
• Languages: English
• ISSNs: 0045-6535

Abstract

Abstract: The relationship between polycyclic aromatic hydrocarbons (PAHs) and hypertension remains a subject of debate. The aims of this study were to determine an association of concentrations of PAHs in housewives' hair with hypertension risk and the modification effect of single nucleotide polymorphisms (SNPs) related to Phase I metabolism of PAHs. We recruited 405 women for a cross-sectional study in Shanxi Province, China, including 170 with hypertension (the case group) and 235 without hypertension (the control group). We analyzed 26 individual PAHs in hair samples and the SNPs of the genes including cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1), CYP1A2, CYP1B1 and CYP2E1. Our results showed that seven PAHs in hair samples were measured with detection rate >70%. Only acenaphthylene was found to be associated with an increased risk of hypertension with adjustment for the potential confounders following Bonferroni correction, whereas others not. No SNPs of the concerned genes were found to be associated with the risk of hypertension. A multiple interaction effect of PAHs in housewives' hair and SNPs on hypertension risk was not observed. It was concluded that PAHs tended to contribute to the formation of hypertension. Graphical abstract: Highlights: Rural housewives expose to high level of indoor air pollution in northern China. We investigated an association of PAHs in housewives' hair with hypertension risk. Phase I enzyme gene polymorphisms related to PAH metabolism were analyzed. PAHs tended to contribute to the risk of hypertension in housewives. None of the concerned genes were found to be associated with hypertension risk.