Cognitive reserve in bipolar disorder: relation to cognition, psychosocial functioning and quality of life. (30th December 2015)

• Record Type: Journal Article
• Authors: Anaya, C.; Torrent, C.; Caballero, F. F.; Vieta, E.; Bonnin, C. del Mar; Ayuso‐Mateos, J. L.
• Other Names: Alegría Analucía investigator.; Amann Benedikt L. investigator.; Al‐Halabi Susana investigator.; Alonso‐Lana Silvia investigator.; Arango Celso investigator.; Balanzá‐Martinez Vicente investigator.; Barbeito Sara investigator.; Bobes Julio investigator.; Díaz‐Caneja Covadonga investigator.; Cerrillo Ester investigator.; Colom Francesc investigator.; Correa Patricia investigator.; Crespo José Manuel investigator.; Custal Núria investigator.; Fernández Patricia investigator.; Fernández Miryam investigator.; Fuentes‐Durá Inmaculada investigator.; Garcia‐Portilla M. Paz investigator.; Galván Gonzalo investigator.; González‐Pinto Ana investigator.; Ibáñez Ángela investigator.; Isella Sandra investigator.; Jiménez Esther investigator.; Landín‐Romero Ramon investigator.; Martínez‐Arán Anabel investigator.; Mayoral María investigator.; Menchón José Manuel investigator.; Merchán‐Naranjo Jessica investigator.; Ortiz‐Gil Jordi investigator.; Pacchiarotti Isabella investigator.; Reyes Raquel investigator.; Rosa Adriane R. investigator.; Rapado‐Castro Marta investigator.; Reinares María investigator.; Rodao José María investigator.; Saiz Pilar A. investigator.; Sánchez‐Moreno José investigator.; Salamero Manel investigator.; Segura Bárbara investigator.; Selva‐Vera Gabriel investigator.; Saiz‐Ruiz Jerónimo investigator.; Solé Brisa investigator.; Soria Virginia investigator.; Subirá Marta investigator.; Tabarés‐Seisdedos Rafael investigator.; Ugarte Amaia investigator.; Valle Jesús investigator.; Vega Patricia investigator.;
• Is Part Of: Acta psychiatrica Scandinavica. Volume 133:Number 5(2016:May)
• Page Start: 386
• Page End: 398
• Publication Date: 2015-12-30
• Subjects: cognitive reserve -- bipolar disorder -- cognition -- social competence -- quality of life; Psychiatry -- Periodicals; 616.89
• DOI: 10.1111/acps.12535
• Languages: English
• ISSNs: 0001-690X

Abstract

Abstract : Objective: Cognitive reserve (CR) is a concept that was postulated as a protective factor for some clinical symptoms after the observation that there is not a direct relationship between the degree of brain damage and its clinical manifestation. This study aimed to explore the association between CR and the main outcomes in bipolar disorder (BD): cognitive functions, psychosocial functioning and perceived quality of life. Method: A sample of 224 euthymic bipolar patients was assessed with a neuropsychological battery, the Functioning Assessment Short Test and the Medical Outcomes Study 36‐Item Short‐Form Health Survey (SF‐36). CR was calculated through three proxies: estimated premorbid Intelligent Quotient, educational level and occupational attainment. Relationships between CR and cognitive functions, psychosocial functioning and quality of life were assessed by multiple linear regression models. Results: Higher CR was associated with better cognitive functioning ( P < 0.001 in processing speed, working memory, verbal and visual memory, and executive function; P = 0.026 in attention) and better psychosocial functioning ( P = 0.008). For quality of life, CR was positively associated with the physical component of the SF‐36 ( P = 0.016) but negatively associated with the mental component ( P = 0.004). Conclusion: The results suggest that CR may play an important role in the course and prognosis of bipolar patients and it should be considered in both clinical and research settings related to BD.