A highly efficient heterogeneous copper-catalyzed three-component coupling of tetrahydroisoquinolines, aldehydes and 1-alkynes. Issue 5 (14th October 2015)

• Record Type: Journal Article
• Authors: Zhao, Hong; He, Wen; Wei, Li; Cai, Mingzhong
• Is Part Of: Catalysis science & technology. Volume 6:Issue 5(2016)
• Page Start: 1488
• Page End: 1495
• Publication Date: 2015-10-14
• Subjects: Catalysis -- Periodicals; 541.395
• DOI: 10.1039/c5cy01342a
• Languages: English
• ISSNs: 2044-4753

Abstract

Abstract : A highly efficient heterogeneous copper-catalyzed three-component coupling of tetrahydroisoquinolines, aldehydes and 1-alkynes has been described. Abstract : A highly efficient heterogeneous three-component coupling of tetrahydroisoquinolines, aldehydes and 1-alkynes was achieved in toluene at 70 °C in the presence of a 3-(2-aminoethylamino)propyl-functionalized MCM-41-supported copper(i ) complex [MCM-41-2N–CuI], yielding a variety of C1-alkynylated tetrahydroisoquinolines ( endo -yne-THIQs) in good to excellent yields with high regioselectivity. This heterogeneous copper catalyst can be easily prepared by a simple two-step procedure from commercially available and inexpensive reagents, and recovered by a simple filtration and reused for at least 10 times without any decrease in activity.