A cumulative genetic risk score predicts progression in Parkinson's disease. Issue 4 (8th February 2016)

• Record Type: Journal Article
• Authors: Pihlstrøm, Lasse; Morset, Kristina Rebekka; Grimstad, Espen; Vitelli, Valeria; Toft, Mathias
• Is Part Of: Movement disorders. Volume 31:Issue 4(2016)
• Page Start: 487
• Page End: 490
• Publication Date: 2016-02-08
• Subjects: Parkinson's disease -- genetics -- GWAS -- progression -- Hoehn and Yahr; Movement disorders -- Periodicals; 610
• DOI: 10.1002/mds.26505
• Languages: English
• ISSNs: 0885-3185

Abstract

Abstract: Background: The contribution of genetic variability to clinical heterogeneity in Parkinson's disease is insufficiently understood. We aimed to investigate the effect of cumulative genetic risk on clinical outcomes. Methods: In a single‐center study of 336 patients we genotyped 19 independent susceptibility variants identified in genome‐wide association studies of Parkinson's disease. We tested for association between a cumulative genetic risk score and 3 outcome measures: survival, time until progression to Hoehn and Yahr stage 3, and Unified Parkinson's Disease Rating Scale motor score severity. Results: Genetic risk score was significantly associated with time from diagnosis to Hoehn and Yahr stage 3 in a Cox regression model ( P = 0.010). We observed no clear association for the other outcomes. Conclusions: We present results linking cumulative genetic risk to a motor outcome in Parkinson's disease. Our findings provide a valuable starting point for future large‐scale efforts to map the genetic determinants of phenotypic variability. © 2016 International Parkinson and Movement Disorder Society