Convenient Synthesis of Spiro[benzo[d]pyrrolo[2, 1‐b]thiazole‐3, 2′‐indenes] Derivatives via Three‐Component Reaction. Issue 4 (14th March 2016)

• Record Type: Journal Article
• Authors: Shen, Guoliang; Sun, Jing; Yan, Chaoguo
• Is Part Of: Chinese journal of chemistry. Volume 34:Issue 4(2016:Apr.)
• Page Start: 412
• Page End: 418
• Publication Date: 2016-03-14
• Subjects: multicomponent reaction -- nitrogen ylide -- spiro compound -- benzothiazole -- indan‐1, 3‐dione; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/cjoc.201500896
• Languages: English
• ISSNs: 1001-604X

Abstract

Abstract: The three‐component reaction of N ‐phenacylbenzothiazolium bromides, aromatic aldehydes and indane‐1, 3‐dione in ethanol at room temperature in the presence of triethylamine as base afforded functionalized spiro[benzo[ d ]pyrrolo[2, 1‐ b ]thiazole‐3, 2′‐indenes] in good yields and with high diastereoselectivity. The 1 H NMR data and single crystal structure clearly indicated that the obtained spiro compounds predominately have one diastereoisomer. Abstract : The three‐component reactions of N ‐phenacylbenzothiazolium bromides, aromatic aldehydes and indane‐1, 3‐dione afforded functionalized spiro[benzo[ d ]pyrrolo[2, 1‐ b ]‐thiazole‐3, 2′‐indenes] in good yields and with high diastereoselectivity.