Synthesis, characterisation, cytotoxicity and antibacterial activity of ruthenium(II) and rhodium(III) complexes with sulfur-containing terpyridines. (9th March 2016)

• Record Type: Journal Article
• Authors: Beloglazkina, Elena K.; Manzheliy, Eugeniy A.; Moiseeva, Anna A.; Maloshitskaya, Olga A.; Zyk, Nikolai V.; Skvortsov, Dmitry A.; Osterman, Ilya A.; Sergiev, Petr V.; Dontsova, Olga A.; Ivanenkov, Yan A.; Veselov, Mark S.; Majouga, Alexander G.
• Is Part Of: Polyhedron. Volume 107(2016)
• Page Start: 27
• Page End: 37
• Publication Date: 2016-03-09
• Subjects: Ruthenium(II) -- Rhodium(III) -- Terpyridines -- Phenanthroline -- Cytotoxicity; Chemistry, Inorganic -- Periodicals; Chimie inorganique -- Périodiques; Organometaalverbindingen; Anorganische chemie; 546.05
• DOI: 10.1016/j.poly.2015.12.059
• Languages: English
• ISSNs: 0277-5387

Abstract

Graphical abstract: Novel thioacetyl-functionalised terpyridine ligands and their ruthenium and rhodium complexes [Ru(tpy)2 ](PF6 )2, [Rh(tpy)2 ](PF6 )3, [Ru(phen)(tpy)Cl](PF6 ), [Rh(phen)(tpy)](PF6 )2 (phen = phenanthroline; tpy = S-[ω-(2, 2:6′, 2″-terpyridin-4′-yl)phenoxy]alkyl ethanethioate) have been described. The crystal structure of [Rh(phen)(tpy)](PF6 )2 (tpy = 4′-phenyl-2, 2′:6′, 2″-terpyridine) was determined by X-ray. The antibacterial and catalytical activity of synthesized complexes were tested. Abstract: The synthesis and characterisation of novel thioacetyl-functionalised terpyridine ligands and their ruthenium and rhodium complexes [Ru(tpy)2 ](PF6 )2, [Rh(tpy)2 ](PF6 )3, [Ru(phen)(tpy)Cl](PF6 ), [Rh(phen)(tpy)Cl](PF6 )2 (phen = phenanthroline; tpy = S-[ω-(2, 2:6′, 2″-terpyridin-4′-yl)phenoxy]alkyl ethanethioate) have been described. Ligands and complexes were characterised by 1 H NMR spectroscopy, mass spectrometry, elemental analysis and cyclic voltammetry data. The crystal structure of the complex [Rh(phen)(tpy)Cl](PF6 )2 (phen = phenanthroline; tpy = 4′-phenyl-2, 2′:6′, 2″-terpyridine) (21 ), have been determined by X-ray crystallography. Complex21 show a distorted octahedral geometry around the ruthenium centre. Antimicrobial activity toward Escherichia coli at concentrations as low as 5 μM was found for some of the studied complexes. For complexes [Rh(tpyC6 H4 O(CH2 )8 SCOCH3 )2 ](PF6 )3 (19 ), [Rh(phen)(tpyC6 H4 O(CH2 )8 SCOCH3 )Cl](PF6 )2 (31 ) and [Rh(phen)(tpyC6 H4 O(CH2 )11 SCOCH3 )Cl](PF6 )2 (32 ), a strong inhibition of in vitro protein synthesis was observed using firefly luciferase. An investigation of cytotoxicity of the complexes against human embryonic kidney cells (HEK293 line) by the MTT assay demonstrates that the toxicity of all tested compounds is of similar magnitude, with IC50 values of 3–30 μM.