DNA‐Based Sensor Particles Enable Measuring Light Intensity in Single Cells. Issue 14 (11th February 2016)

• Record Type: Journal Article
• Authors: Mikutis, Gediminas; Mora, Carlos A.; Puddu, Michela; Paunescu, Daniela; Grass, Robert N.; Stark, Wendelin J.
• Is Part Of: Advanced materials. Volume 28:Issue 14(2016)
• Page Start: 2765
• Page End: 2770
• Publication Date: 2016-02-11
• Subjects: caged oligonucleotides -- sensor particles -- light sensors -- nanosensor -- single cell analysis; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.201504892
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract : "Lab on a particle" architecture is employed in designing a light nanosensor. Light‐sensitive protecting groups are installed on DNA, which is encapsulated in silica particles, qualifying as a self‐sufficient light sensor. The nanosensors allow measuring light intensity and duration in very small volumes, such as single cells, and store the irradiation information until readout.