Preparation and evaluation of liver-targeting micelles loaded with oxaliplatin*. (17th February 2016)

• Record Type: Journal Article
• Authors: Yan, Guowen; Chen, Qian; Xu, Lisa; Wei, Haitian; Ma, Chao; Sun, Yong
• Is Part Of: Artificial cells, nanomedicine, and biotechnology. Volume 44:Number 2(2016)
• Page Start: 491
• Page End: 496
• Publication Date: 2016-02-17
• Subjects: nanoparticle -- oxaliplatin -- pharmacokinetics -- tumor; Artificial cells -- Periodicals; Nanotechnology -- Periodicals; Blood substitutes -- Periodicals; Tissue engineering -- Periodicals; Molecules -- Periodicals; Biotechnology -- Periodicals; 615.39
• DOI: 10.3109/21691401.2014.962747
• Languages: English
• ISSNs: 2169-1401

Abstract

Abstract : We prepared liver-targeting micelles loaded with oxaliplatin (OXA), using a polymer modified by a liver-targeting ligand, namely, glycyrrhetinic acid-conjugated and stearic acid-grafted chitosan (GA-CS-SA). The particles had a uniform size, which was 138.6 ± 0.72 nm. The encapsulation efficiency was up to 71.7 ± 0.46%. The hepatic distribution of OXA in mice given OXA-GA-CS-SA was significantly superior to that in the controls ( P < 0.05), which means that liver-targeted delivery of OXA was achieved. These results reveal that OXA-GA-CS-SA could be a potential and promising candidate for efficiently targeted delivery of OXA.