An analytical comparison between point-of-care uric acid testing meters. (3rd March 2016)

• Record Type: Journal Article
• Authors: Paraskos, Jonathan; Berke, Zsofia; Cook, Jason; Miner, Jeffrey N.; Braddock, Martin; Platt, Adam; Hughes, Glen
• Is Part Of: Expert review of molecular diagnostics. Volume 16:Number 3(2016)
• Page Start: 373
• Page End: 382
• Publication Date: 2016-03-03
• Subjects: Uric acid -- diagnostic test -- point-of-care systems -- gout; Molecular diagnosis -- Periodicals; 616.0758205
• DOI: 10.1586/14737159.2016.1134326
• Languages: English
• ISSNs: 1473-7159

Abstract

ABSTRACT: Objective : A key goal in gout treatment is achieving sustained serum uric acid (sUA) lowering. Point-of-care test (PoCT) meters provide convenient, rapid measures of sUA levels to monitor/adjust therapy. Four commercially available sUA PoCT meters were compared qualitatively (ease of use) and quantitatively (precision/accuracy). Methods : Liquid chromatography mass spectrometry (LC-MS) analysis was used as a laboratory reference method to compare precision of PoCT devices using blood samples from 20 healthy volunteers. Accuracy was compared against the LC-MS reference method and a laboratory clinical chemistry platform. Results : Qualitatively, EasyTouch ® GU and UA Sure were least user-friendly, requiring repeated attempts for accurate use. HumaSens and BeneCheck provided good usability and assay precision. Cross-validation of meter precision with laboratory-based uricase assay gave good correlations between both methods (R 2 = 0.8061 and 0.7605, respectively). Conclusion : UA PoCT meters can be important in managing gout, and the characteristics compared herein may enhance successful patient uptake.