Infective Endocarditis in Children in Italy from 2000 to 2015. Issue 3 (3rd March 2016)

• Record Type: Journal Article
• Authors: Esposito, Susanna; Mayer, Alessandra; Krzysztofiak, Andrzej; Garazzino, Silvia; Lipreri, Rita; Galli, Luisa; Osimani, Patrizia; Fossali, Emilio; Di Gangi, Maria; Lancella, Laura; Denina, Marco; Pattarino, Giulia; Montagnani, Carlotta; Salvini, Filippo; Villani, Alberto; Principi, Nicola; for the Italian Pediatric Infective Endocarditis Registry,
• Is Part Of: Expert review of anti-infective therapy. Volume 14:Issue 3(2016)
• Page Start: 353
• Page End: 358
• Publication Date: 2016-03-03
• Subjects: antibiotics -- anti-infective therapy -- congenital heart disease -- infective endocarditis -- Staphylococcus aureus -- viridans Streptococci; Anti-infective agents -- Research -- Periodicals; 616.90461
• DOI: 10.1586/14787210.2016.1136787
• Languages: English
• ISSNs: 1478-7210

Abstract

ABSTRACT: Objective : The Italian Society for Pediatric Infectious Diseases created a registry on children with infective endocarditis (IE) hospitalized in Italy. Methods : A cross-sectional survey was conducted on patients hospitalized due to IE in Italian paediatric wards between January 1, 2000, and June 30, 2015. Results : Over the 15-year study period, 47 IE episodes were observed (19 males; age range, 2-17 years). Viridans Streptococci were the most common pathogens among patients with predisposing cardiac conditions and Staphylococcus aureus among those without (37.9% vs. 5.5%, p = 0.018, and 6.9% vs. 27.8%, p = 0.089, respectively). Six of the 7 (85.7%) S. aureus strains were methicillin-resistant. The majority of patients with and without predisposing cardiac conditions recovered without any complications. Conclusion : In Italy, paediatric IE develops without any previous predisposing factors in a number of children, methicillin-resistant S. aureus has emerged as a common causative agent and the therapeutic approach is extremely variable.