Novel insights into human respiratory syncytial virus-host factor interactions through integrated proteomics and transcriptomics analysis. Issue 3 (3rd March 2016)

• Record Type: Journal Article
• Authors: Dapat, Clyde; Oshitani, Hitoshi
• Is Part Of: Expert review of anti-infective therapy. Volume 14:Issue 3(2016)
• Page Start: 285
• Page End: 297
• Publication Date: 2016-03-03
• Subjects: Respiratory syncytial virus -- human -- Virus-host interactions -- Microarray analysis -- Proteomics -- Protein-protein interaction network -- Drug-drug target interaction network; Anti-infective agents -- Research -- Periodicals; 616.90461
• DOI: 10.1586/14787210.2016.1141676
• Languages: English
• ISSNs: 1478-7210

Abstract

ABSTRACT: The lack of vaccine and limited antiviral options against respiratory syncytial virus (RSV) highlights the need for novel therapeutic strategies. One alternative is to develop drugs that target host factors required for viral replication. Several microarray and proteomics studies had been published to identify possible host factors that are affected during RSV replication. In order to obtain a comprehensive understanding of RSV-host interaction, we integrated available proteome and transcriptome datasets and used it to construct a virus-host interaction network. Then, we interrogated the network to identify host factors that are targeted by the virus and we searched for drugs from the DrugBank database that interact with these host factors, which may have potential applications in repositioning for future treatment options of RSV infection.