A Main Group Gallium(III) Complex Derived from 2-Acetylpyrazine N4-phenylthiosemicarbazone: Synthesis, Crystal Structure and Biological Evaluation. Issue 5 (3rd May 2016)

• Record Type: Journal Article
• Authors: Lu, Yanli; Ma, Pengtao; Li, Mingxue; Chen, Danyun; Zou, Xueyan
• Is Part Of: Synthesis and reactivity in inorganic, metal-organic, and nano-metal chemistry. Volume 46:Issue 5(2016)
• Page Start: 718
• Page End: 724
• Publication Date: 2016-05-03
• Subjects: thiosemicarbazone -- gallium(III) -- crystal structure -- cytotoxicity -- apoptosis; Inorganic compounds -- Synthesis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Organometallic compounds -- Synthesis -- Periodicals; Reactivity (Chemistry) -- Periodicals; Nanostructured materials -- Periodicals; 541.39
• DOI: 10.1080/15533174.2014.989585
• Languages: English
• ISSNs: 1553-3174

Abstract

Abstract : Up to now, main group gallium(III) complexes with thiosemicarbazones have been comparatively rare. Here, a main group six-coordinated gallium(III) complex [Ga(L)2 ]NO3 ·H2 O (1 ) (HL = 2-acetylpyrazine N 4 -phenylthiosemicarbazone) has been synthesized and characterized by elemental analysis, IR and UV/Vis spectroscopy, mass spectrometry, and single-crystal X-ray diffraction. The cytotoxicity data suggest that 1 exhibits significant antiproliferative activity in vitro against three human cancer cells. Its possible apoptotic mechanism has been evaluated in HepG2 cells.1 induces a dose-dependent apoptosis in HepG2 cells and the apoptosis is associated with reduction of mitochondrial membrane potential.