Oleuropein alleviates malathion-induced oxidative stress and DNA damage in rats. Issue 1 (2nd January 2016)

• Record Type: Journal Article
• Authors: Karabag-Coban, Funda; Bulduk, Ibrahim; Liman, Recep; Ince, Sinan; Cigerci, Ibrahim; Hazman, Omer
• Is Part Of: Toxicological and environmental chemistry. Volume 98:Issue 1(2016)
• Page Start: 101
• Page End: 108
• Publication Date: 2016-01-02
• Subjects: malathion -- oleuropein -- oxidative stress -- DNA damage -- rat; Toxicology -- Periodicals; Environmental chemistry -- Periodicals; 571.95
• DOI: 10.1080/02772248.2015.1110156
• Languages: English
• ISSNs: 0277-2248

Abstract

Abstract : The effects of acute exposure to 250 mg/kg malathion and the protective effects of 20 mg/kg oleuropein, both administered intraperitoneally, were evaluated in Wistar male rats. Malathion administration increased malondialdehyde, nitric oxide, 8-hydroxy-2′-deoxyguanosine, total oxidant status, and DNA damage, yet decreased total antioxidant activity, superoxide dismutase, and catalase activities in blood, liver, and kidney. Administration of oleuropein reversed malathion-induced oxidative stress, lipid peroxidation, DNA damage, and antioxidant enzyme activity.