Assuring the Proper Analytical Performance of Measurement Procedures for Immunosuppressive Drug Concentrations in Clinical Practice: Recommendations of the International Association of Therapeutic Drug Monitoring and Clinical Toxicology Immunosuppressive Drug Scientific Committee. Issue 2 (April 2016)

• Record Type: Journal Article
• Authors: Seger, Christoph; Shipkova, Maria; Christians, Uwe; Billaud, Elaine M.; Wang, Ping; Holt, David W.; Brunet, Mercè; Kunicki, Paweł K.; Pawiński, Thomasz; Langman, Loralie J.; Marquet, Pierre; Oellerich, Michael; Wieland, Eberhard; Wallemacq, Pierre
• Is Part Of: Therapeutic drug monitoring. Volume 38:Issue 2(2016:Apr.)
• Publication Date: 2016-04
• Subjects: TDM -- immunosuppressant drugs -- cyclosporine -- tacrolimus -- sirolimus -- everolimus -- mycophenolic acid -- LC-MS/MS -- immunoassay -- design -- validation -- verification; Pharmacokinetics -- Periodicals; Patient monitoring -- Periodicals; Drugs -- Analysis -- Periodicals; Body fluids -- Analysis -- Periodicals; Drug Therapy -- Periodicals; Monitoring, Physiologic -- Periodicals; Pharmacology -- Periodicals; 615.7
• DOI: 10.1097/FTD.0000000000000269
• Languages: English
• ISSNs: 0163-4356

Abstract

Abstract : Abstract: Monitoring immunosuppressive drugs (ISDs) in blood or plasma is still a key therapeutic drug monitoring (TDM) application in clinical settings. Narrow target ranges and severe side effects at drug underexposure or overexposure make accurate and precise measurements a must. This overview prepared by the Immunosuppressive Drugs Scientific Committee of the International Association of Therapeutic Drug Monitoring and Clinical Toxicology is intended to serve as a summary and guidance document describing the current state-of-the-art in the TDM of ISDs.