Mono- and dinuclear gadolinium(III) complexes of tris(4-carboxy-3-benzyl-3-azabutyl) amine: Synthesis and relaxation properties. (9th March 2016)

• Record Type: Journal Article
• Authors: Makita, Yoshimasa; Inoue, Masashi; Katayama, Natsuki; Lee, Hsien-Han; Abe, Taro; Inui-Yamamoto, Chizuko; Mori, Yuki; Yoshioka, Yoshichika; Honda, Yoshitomo; Gamoh, Shoko; Shimizutani, Kimishige; Fujiwara, Shin-ichi; Ogawa, Akiya
• Is Part Of: Polyhedron. Volume 107(2016)
• Page Start: 148
• Page End: 152
• Publication Date: 2016-03-09
• Subjects: MRI magnetic resonance imaging -- DTPA diethylenetriaminepentaacetic acid -- DOTA 1, 4, 7, 10-tetraazacyclododecane-1, 4, 7, 10-tetraacetic acid -- H3L tris(4-carboxy-3-benzyl-3-azabutyl) amine -- TR repetition time -- TE echo time -- T1 longitudinal relaxation time -- DMEM Dulbecco's modified essential medium -- FBS fetal bovine serum -- R1 relaxivity; Gadolinium complex -- Nonionic -- Relaxivity -- Cytotoxicity -- MRI contrast agent; Chemistry, Inorganic -- Periodicals; Chimie inorganique -- Périodiques; Organometaalverbindingen; Anorganische chemie; 546.05
• DOI: 10.1016/j.poly.2015.12.064
• Languages: English
• ISSNs: 0277-5387

Abstract

Graphical abstract: A mononuclear complex and a dinuclear complex of gadolinium with tris(4-carboxy-3-benzyl-3-azabutyl) amine ligand were synthesized. The structure of the dinuclear complex was determined by X-ray crystal structure analysis. Abstract: In this study, tris(4-carboxy-3-benzyl-3-azabutyl) amine—a novel polyaminocarboxylate ligand—was synthesized. Two new nonionic complexes (a mononuclear complex and a dinuclear complex) of gadolinium with this ligand were also synthesized as potential magnetic resonance imaging (MRI) contrast agents. The structure of the dinuclear complex was determined by X-ray crystal structure analysis. The relaxivity and cytotoxicity of the mono- and dinuclear complexes were evaluated.