Assisted reproductive outcomes in women with different polycystic ovary syndrome phenotypes: the predictive value of anti-Müllerian hormone. Issue 5 (May 2016)

• Record Type: Journal Article
• Authors: Ramezanali, Fariba; Ashrafi, Mahnaz; Hemat, Mandana; Arabipoor, Arezoo; Jalali, Samaneh; Moini, Ashraf
• Is Part Of: Reproductive biomedicine online. Volume 32:Issue 5(2016)
• Page Start: 503
• Page End: 512
• Publication Date: 2016-05
• Subjects: anti-Müllerian hormone -- assisted reproductive technology outcome -- luteinizing hormone/follicle-stimulating hormone ratio -- phenotypes -- polycystic ovary syndrome; Human reproductive technology -- Periodicals; Human embryo -- Periodicals; Reproduction -- Periodicals; 616.692
• DOI: 10.1016/j.rbmo.2016.01.010
• Languages: English
• ISSNs: 1472-6483

Abstract

Abstract: This cross-sectional study aimed to evaluate IVF/intracytoplasmic sperm injection (ICSI) outcomes in different polycystic ovary syndrome (PCOS) phenotypes (A, B, C and D) compared with a control group and the predictive values of serum anti-Müllerian hormone (AMH) in PCOS phenotypes for main outcomes. This study evaluated 386 PCOS women and 350 patients with male factor infertility. Women with phenotypes A and C had significantly higher concentrations of AMH than those with phenotype B ( P < 0.001). Clinical pregnancy rate (CPR) in the phenotype D group (53.3%) was higher than other groups (32.5%, 26.4% and 36.8%, respectively, in phenotypes A, B and C), but not to a significant level. Multivariable regression analysis, after adjusting for women's age and body mass index, revealed that PCOS phenotypes A and B were associated with a decreased CPR compared with the control group (odds ratio [OR]: 0.46, confidence interval [CI]: 0.26–0.8, P = 0.007 and OR: 0.34, CI: 0.18–0.62, P = 0.001, respectively). It seems a combination of hyperandrogenism and chronic anovulation is associated with a negative impact on the CPR in these patients. These results demonstrated that AMH concentration is related to PCO morphology but not predictive for CPR and live birth rate.