Significance of chemokine and chemokine receptors in head and neck squamous cell carcinoma: A critical review. (May 2016)

• Record Type: Journal Article
• Authors: da Silva, Janine Mayra; Soave, Danilo Figueiredo; Moreira dos Santos, Tálita Pollyanna; Batista, Aline Carvalho; Russo, Remo Castro; Teixeira, Mauro Martins; Silva, Tarcília Aparecida da
• Is Part Of: Oral oncology. Volume 56(2016:May.)
• Page Start: 8
• Page End: 16
• Publication Date: 2016-05
• Subjects: SCC squamous cell carcinoma -- HNSCC head and neck squamous cell carcinoma -- OSCC oral squamous cell carcinoma -- CAF's carcinoma associated fibroblasts -- MMP-9 matrix metalloproteinase-9 -- PI3K phosphoinositide 3-kinase -- AKT/PKB protein kinase b -- MAPK'S mitogen activated protein kinases -- EGFR epidermal growth factor receptor -- EMT epithelial–mesenquimal transition -- SNP'S single nucleotide polymorphisms -- OLK oral leukoplakia -- ERK1/2 extracellular signal-regulated kinase -- NF-KB nuclear factor kappa-light-chain-enhancer of activated b cells -- FDA food and drug administration; Head and neck squamous cell carcinoma -- Chemokines -- Inflammation; Mouth -- Cancer -- Periodicals; Mouth -- Tumors -- Periodicals; Mouth Diseases -- Periodicals; Mouth Neoplasms -- Periodicals; Bouche -- Cancer -- Périodiques; Bouche -- Tumeurs -- Périodiques; Tumeurs -- Périodiques; Electronic journals; 616.9943105
• DOI: 10.1016/j.oraloncology.2016.02.016
• Languages: English
• ISSNs: 1368-8375

Abstract

Highlights: We reviewed current knowledge in the literature on OSCC and chemokines. The chemokine and chemokine/receptor system play key roles on oral tumogigenesis. Therapies directed at chemokines and its receptors may be a novel approach in the treatment of oral cancer. Summary: Chemokines are small chemotactic proteins that coordinate circulation of immune/inflammatory cells throughout body compartments. Because of this property chemokines and their cell surface receptors are implicated in several physiological and pathological conditions, including cancer. These molecules are expressed by neoplastic or stromal cells and have effects at tumor primary site (e.g. stimulating angiogenesis and tumor cells motility) and lymph nodes (creating a gradient to direct migration of neoplastic cells). In this article we review the current knowledge about the function(s) of chemokines and receptors in squamous cell carcinoma from the oral cavity and head and neck region. Accumulating evidence suggests some chemokine(s) and receptor(s) as potential targets in adjuvant therapies for these malignancies.